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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:4781
Term: emetine
Definition: A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.
Chemical ID: MESH:D004640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases activityISOMMP2 (Homo sapiens)6480464CTDEmetine results in decreased activity of MMP2 proteinPMID:26332055
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDEmetine results in decreased expression of MMP2 mRNAPMID:26332055
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDMAPK14 mutant form inhibits the reaction [Emetine results in decreased activity of MMP2 protein]PMID:26332055
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