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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631409
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsp90aa1
Name: heat shock protein 90 alpha family class A member 1
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsp90aa1increases acetylationISOHSP90AA1 (Homo sapiens)6480464CTDsulforaphane results in increased acetylation of HSP90AA1 proteinPMID:19805354
Hsp90aa1increases expressionISOHSP90AA1 (Homo sapiens)6480464CTDsulforaphane results in increased expression of HSP90AA1 mRNAPMID:31838189
Hsp90aa1multiple interactionsISOHSP90AA1 (Homo sapiens)6480464CTDsulforaphane inhibits the reaction [HSP90AA1 protein binds to AR protein]; sulforaphane promotes the reaction [Arsenic Trioxide results in increased expression of HSP90AA1 protein]PMID:19805354 PMID:22922937
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