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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrincreases activityEXP 6480464CTDsulforaphane results in increased activity of GSR proteinPMID:22664424 PMID:37385402
Gsrmultiple interactionsEXP 6480464CTDsulforaphane inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of GSR protein]PMID:30835071
Gsrdecreases activityISOGSR (Homo sapiens)6480464CTDsulforaphane results in decreased activity of GSR proteinPMID:17937621
Gsrincreases expressionISOGSR (Homo sapiens)6480464CTDsulforaphane results in increased expression of GSR mRNAPMID:26833863 PMID:31838189
Gsrincreases expressionISOGsr (Mus musculus)6480464CTDsulforaphane results in increased expression of GSR mRNAPMID:19303893 PMID:28710020
Gsrmultiple interactionsISOGsr (Mus musculus)6480464CTDsulforaphane inhibits the reaction [Oxidopamine results in decreased activity of GSR protein]PMID:23518299
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