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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1increases expressionISOCyp2e1 (Mus musculus)6480464CTDsulforaphane results in increased expression of CYP2E1 mRNAPMID:30529165
Cyp2e1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTDsulforaphane inhibits the reaction [cyanoginosin LR results in increased expression of CYP2E1 mRNA]; sulforaphane inhibits the reaction [cyanoginosin LR results in increased expression of CYP2E1 protein]PMID:21684301
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