RGD Gene Chemical Interaction Report

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Keyword

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	10473
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Nqo1
Name:	NAD(P)H dehydrogenase, quinone 1

Acc ID:	CHEBI:47807
Term:	sulforaphane
Definition:	A sulfoxide that has formula C6H11NOS2.
CasRN:	4478-93-7
Chemical ID:	MESH:C016766

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	ISO	RGD:735868	6480464	CTD	sulforafan results in increased activity of NQO1 protein	PMID:20868228
increases expression	ISO	RGD:735868	6480464	CTD	sulforafan results in increased expression of NQO1 mRNA	PMID:19033392 PMID:15896333 PMID:20442190 PMID:15672752
multiple interactions	EXP		6480464	CTD	NFE2L2 protein promotes the reaction [sulforafan results in increased expression of NQO1 mRNA]	PMID:20932822
affects localization	EXP		6480464	CTD	sulforafan affects the localization of NQO1 protein	PMID:19367690
increases activity	EXP		6480464	CTD	sulforafan results in increased activity of NQO1 protein	PMID:19367690 PMID:18838692
increases expression	EXP		6480464	CTD	sulforafan results in increased expression of NQO1 protein	PMID:11309284 PMID:19367690
multiple interactions	EXP		6480464	CTD	Vanadium inhibits the reaction [sulforafan affects the localization of NQO1 protein] Vanadium inhibits the reaction [sulforafan results in increased activity of NQO1 protein] Vanadium inhibits the reaction [sulforafan results in increased expression of NQO1 protein] Vanadium inhibits the reaction [sulforafan results in increased expression of NQO1 mRNA]	PMID:19367690
increases expression	EXP		6480464	CTD	sulforafan results in increased expression of NQO1 mRNA	PMID:19367690
increases activity	ISO	RGD:2503	6480464	CTD	sulforafan results in increased activity of NQO1 protein	PMID:15906351
increases expression	ISO	RGD:2503	6480464	CTD	sulforafan results in increased expression of NQO1 mRNA	PMID:11264000
increases expression	ISO	RGD:735868	6480464	CTD	sulforafan results in increased expression of NQO1 mRNA	PMID:19033392 PMID:20442190 PMID:15672752 PMID:15896333
increases activity	EXP		6480464	CTD	sulforafan results in increased activity of NQO1 protein	PMID:21803983 PMID:18838692 PMID:19367690
increases expression	EXP		6480464	CTD	sulforafan results in increased expression of NQO1 protein	PMID:21803983 PMID:11309284 PMID:19367690
increases expression	ISO	RGD:735868	6480464	CTD	sulforafan results in increased expression of NQO1 mRNA	PMID:15896333 PMID:20442190 PMID:19033392 PMID:15672752
increases activity	EXP		6480464	CTD	sulforafan results in increased activity of NQO1 protein	PMID:21803983 PMID:19367690 PMID:18838692
increases expression	EXP		6480464	CTD	sulforafan results in increased expression of NQO1 protein	PMID:19367690 PMID:11309284 PMID:21803983
increases expression	ISO	RGD:735868	6480464	CTD	sulforafan results in increased expression of NQO1 mRNA	PMID:15672752 PMID:15896333 PMID:19033392 PMID:20442190
increases activity	EXP		6480464	CTD	sulforafan results in increased activity of NQO1 protein	PMID:19367690 PMID:21803983 PMID:18838692
increases expression	EXP		6480464	CTD	sulforafan results in increased expression of NQO1 protein	PMID:11309284 PMID:21803983 PMID:19367690
increases activity	ISO	RGD:2503	6480464	CTD	sulforafan results in increased activity of NQO1 protein	PMID:20833222 PMID:15906351
multiple interactions	ISO	RGD:735868	6480464	CTD	sulforafan results in increased expression of and results in increased activity of NQO1 protein Mercuric Chloride promotes the reaction [sulforafan results in increased expression of and results in increased activity of NQO1 protein] Mercuric Chloride promotes the reaction [sulforafan results in increased expression of NQO1 mRNA]	PMID:21843634
increases expression	ISO	RGD:735868	6480464	CTD	sulforafan results in increased expression of NQO1 mRNA	PMID:21843634 PMID:19033392 PMID:20442190 PMID:15672752 PMID:15896333
increases activity	EXP		6480464	CTD	sulforafan results in increased activity of NQO1 protein	PMID:19367690 PMID:18838692 PMID:21803983
increases activity	ISO	RGD:2503	6480464	CTD	sulforafan results in increased activity of NQO1 protein	PMID:15906351 PMID:20833222
increases expression	ISO	RGD:735868	6480464	CTD	sulforafan results in increased expression of NQO1 mRNA	PMID:15672752 PMID:15896333 PMID:21843634 PMID:20442190 PMID:19033392
increases expression	EXP		6480464	CTD	sulforafan results in increased expression of NQO1 mRNA	PMID:19303893 PMID:19071154 PMID:19367690
increases expression	EXP		6480464	CTD	sulforafan results in increased expression of NQO1 protein	PMID:19303893 PMID:21803983 PMID:19367690 PMID:11309284
increases expression	ISO	RGD:2503	6480464	CTD	sulforafan results in increased expression of NQO1 mRNA	PMID:11264000 PMID:19303893
increases expression	ISO	RGD:2503	6480464	CTD	sulforafan results in increased expression of NQO1 protein	PMID:19303893
multiple interactions	EXP		6480464	CTD	NFE2L2 mutant form inhibits the reaction [sulforafan results in increased expression of NQO1 protein]	PMID:20600217
increases activity	EXP		6480464	CTD	sulforafan results in increased activity of NQO1 protein	PMID:18838692 PMID:19367690 PMID:21803983
increases expression	EXP		6480464	CTD	sulforafan results in increased expression of NQO1 protein	PMID:11309284 PMID:19303893 PMID:19367690 PMID:20600217 PMID:21684301 PMID:21803983
increases expression	EXP		6480464	CTD	sulforafan results in increased expression of NQO1 mRNA	PMID:19071154 PMID:19303893 PMID:19367690 PMID:21684301
multiple interactions	ISO	RGD:735868	6480464	CTD	cyanoginosin LR promotes the reaction [sulforafan results in increased expression of NQO1 protein] NFE2L2 mutant form inhibits the reaction [sulforafan results in increased expression of NQO1 protein]	PMID:20600217
multiple interactions	ISO	RGD:735868	6480464	CTD	sulforafan results in increased expression of and results in increased activity of NQO1 protein	PMID:20599494 PMID:21843634
increases expression	ISO	RGD:735868	6480464	CTD	sulforafan results in increased expression of NQO1 protein	PMID:20600217
increases expression	ISO	RGD:735868	6480464	CTD	sulforafan results in increased expression of NQO1 mRNA	PMID:15672752 PMID:15896333 PMID:19033392 PMID:20442190 PMID:20599494 PMID:21843634
multiple interactions	ISO	RGD:735868	6480464	CTD	ammonium metavanadate inhibits the reaction [sulforafan results in increased expression of and results in increased activity of NQO1 protein] ammonium metavanadate inhibits the reaction [sulforafan results in increased expression of NQO1 mRNA]	PMID:20599494
increases expression	ISO	RGD:2503	6480464	CTD	sulforafan results in increased expression of NQO1 protein	PMID:19303893 PMID:20600217
increases activity	ISO	RGD:2503	6480464	CTD	sulforafan results in increased activity of NQO1 protein	PMID:15906351 PMID:20833222 PMID:22664424
increases expression	ISO	RGD:735868	6480464	CTD	sulforafan results in increased expression of NQO1 protein	PMID:20600217 PMID:22558124
increases expression	ISO	RGD:2503	6480464	CTD	sulforafan results in increased expression of NQO1 protein	PMID:19303893 PMID:20600217 PMID:22558124
increases expression	ISO	RGD:735868	6480464	CTD	sulforafan results in increased expression of NQO1 mRNA	PMID:15672752 PMID:15896333 PMID:18417180 PMID:19033392 PMID:20442190 PMID:20599494 PMID:21464939 PMID:21843634
multiple interactions	EXP		6480464	CTD	[Streptozocin co-treated with sulforafan] results in increased expression of NQO1	PMID:22023613
increases expression	EXP		6480464	CTD	sulforafan results in increased expression of NQO1	PMID:22023613

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