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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2845
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr1a
Name: 5-hydroxytryptamine receptor 1A
Acc ID: CHEBI:47781
Term: desipramine
Definition: A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Chemical ID: MESH:D003891
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr1aincreases expressionEXP 6480464CTDDesipramine results in increased expression of HTR1A proteinPMID:1589591
Htr1amultiple interactionsISOHTR1A (Homo sapiens)6480464CTDDesipramine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A mRNA]; Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A protein]PMID:15885359
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