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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11307 Species: Mus musculus RGD Object: Gene Symbol: Slc2a3 Name: solute carrier family 2 (facilitated glucose transporter), member 3

Acc ID: CHEBI:47780 Term: clomipramine Definition: A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias. CasRN: 303-49-1 Chemical ID: MESH:D002997

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:737055	6480464	CTD	Clomipramine results in decreased expression of SLC2A3 mRNA	PMID:15342952
decreases expression	ISO	RGD:737055	6480464	CTD	Clomipramine results in decreased expression of SLC2A3 mRNA	PMID:15342952 PMID:17175557