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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70494
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tert
Name: telomerase reverse transcriptase
Acc ID: CHEBI:4775
Term: ellagic acid
Definition: An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates.
Chemical ID: MESH:D004610
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tertmultiple interactionsEXP 6480464CTDEllagic Acid inhibits the reaction [phosalone results in decreased activity of TERT protein]PMID:27965107
Tertincreases expressionISOTERT (Homo sapiens)6480464CTDEllagic Acid results in increased expression of TERT mRNA alternative formPMID:19501078
Tertmultiple interactionsISOTERT (Homo sapiens)6480464CTDEllagic Acid inhibits the reaction [Estradiol results in increased expression of TERT mRNA alternative form]PMID:19501078
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