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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3281
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pde4d
Name: phosphodiesterase 4D
Acc ID: CHEBI:47657
Term: roflumilast
Definition: A benzamide obtained by formal condensation of the carboxy group of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid with the amino group of 3,5-dichloropyridin-4-amine. Used for treatment of bronchial asthma and chronic obstructive pulmonary disease.
Chemical ID: MESH:C424423
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pde4ddecreases activityISOPDE4D (Homo sapiens)6480464CTDRoflumilast results in decreased activity of PDE4D proteinPMID:15901792
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