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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61817 Species: Rattus norvegicus RGD Object: Gene Symbol: Col1a1 Name: collagen, type I, alpha 1

Acc ID: CHEBI:47612 Term: bezafibrate Definition: A monocarboxylic acid amide that has formula C19H20ClNO4. CasRN: 41859-67-0 Chemical ID: MESH:D001629

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:62109	6480464	CTD	Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of COL1A1 mRNA]	PMID:18513333
increases expression	ISO	RGD:62109	6480464	CTD	Bezafibrate results in increased expression of COL1A1 mRNA	PMID:21499286
multiple interactions	EXP		6480464	CTD	Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]	PMID:18513333