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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2100 Species: Rattus norvegicus RGD Object: Gene Symbol: Alpl Name: alkaline phosphatase, liver/bone/kidney

Acc ID: CHEBI:47612 Term: bezafibrate Definition: A monocarboxylic acid amide that has formula C19H20ClNO4. CasRN: 41859-67-0 Chemical ID: MESH:D001629

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:1346147	6480464	CTD	Bezafibrate results in decreased activity of ALPL protein	PMID:8102192
multiple interactions	ISO	RGD:731885	6480464	CTD	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Bezafibrate results in increased expression of ALPL mRNA] GSK0660 inhibits the reaction [Bezafibrate results in increased expression of ALPL mRNA]	PMID:21499286
increases expression	ISO	RGD:731885	6480464	CTD	Bezafibrate results in increased expression of ALPL mRNA	PMID:21499286