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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731071 Species: Homo sapiens RGD Object: Gene Symbol: AHR Name: aryl hydrocarbon receptor

Acc ID: CHEBI:47519 Term: cis-ketoconazole Definition: null CasRN: 65277-42-1 Chemical ID: MESH:D007654

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]] AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of IL8 protein]] Ketoconazole results in increased activity of and results in increased localization of AHR protein [Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein	PMID:21753779
multiple interactions	ISO	RGD:10127	6480464	CTD	Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]	PMID:17505019
multiple interactions	ISO	RGD:2074	6480464	CTD	Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR mRNA] Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein] Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]	PMID:17505019