GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ahr | increases expression | EXP | | 6480464 | CTD | Ketoconazole results in increased expression of AHR mRNA | PMID:31168027 | Ahr | multiple interactions | EXP | | 6480464 | CTD | Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein] | PMID:17505019 | Ahr | increases activity | ISO | Ahr (Mus musculus) | 6480464 | CTD | Ketoconazole results in increased activity of AHR protein | PMID:25000292 | Ahr | increases activity | ISO | AHR (Homo sapiens) | 6480464 | CTD | Ketoconazole results in increased activity of AHR protein | PMID:25000292 | Ahr | multiple interactions | ISO | Ahr (Mus musculus) | 6480464 | CTD | AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein] | PMID:17505019 PMID:17923278 | Ahr | multiple interactions | ISO | AHR (Homo sapiens) | 6480464 | CTD | [Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; Ketoconazole results in increased activity of and results in increased localization of AHR protein | PMID:21753779 | | ||||||||||||||||||||||
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