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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:47381
Term: diclofenac
Definition: A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Chemical ID: MESH:D004008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2multiple interactionsEXP 6480464CTDABCC2 protein results in increased transport of and results in increased metabolism of and results in increased susceptibility to DiclofenacPMID:25450747
Abcc2decreases activityISOABCC2 (Homo sapiens)6480464CTDDiclofenac results in decreased activity of ABCC2 proteinPMID:22646477
Abcc2increases expressionISOABCC2 (Homo sapiens)6480464CTDDiclofenac results in increased expression of ABCC2 mRNAPMID:19022234
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