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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737190 Species: Mus musculus RGD Object: Gene Symbol: Agtr1a Name: angiotensin II receptor, type 1a

Acc ID: CHEBI:472805 Term: ouabain Definition: A multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+(/K)+)-ATPase (sodium pump). CasRN: 630-60-4 Chemical ID: MESH:D010042

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:2070	6480464	CTD	Ouabain results in decreased expression of AGTR1A protein	PMID:16565308
affects expression	ISO	RGD:2070	6480464	CTD	Ouabain affects the expression of AGTR1A mRNA	PMID:16565308
decreases expression	ISO		6480464	CTD	Ouabain results in decreased expression of AGTR1A protein	PMID:16565308
affects expression	ISO		6480464	CTD	Ouabain affects the expression of AGTR1A mRNA	PMID:16565308