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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349 Species: Rattus norvegicus RGD Object: Gene Symbol: Ptgs2 Name: prostaglandin-endoperoxide synthase 2

Acc ID: CHEBI:46727 Term: quartz Definition: null CasRN: 14808-60-7 Chemical ID: MESH:D011791

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Curcumin inhibits the reaction [Quartz results in increased expression of PTGS2 mRNA]	PMID:18001810
increases expression	EXP		6480464	CTD	Quartz results in increased expression of PTGS2 mRNA	PMID:18001810
multiple interactions	ISO	RGD:731007	6480464	CTD	[Quartz co-treated with Ascorbic Acid] results in increased expression of PTGS2 mRNA [Quartz co-treated with Ascorbic Acid] results in increased expression of PTGS2 protein	PMID:17222177
increases expression	ISO	RGD:731007	6480464	CTD	Quartz results in increased expression of PTGS2 protein	PMID:17222177
multiple interactions	EXP		6480464	CTD	[Quartz co-treated with Ascorbic Acid] results in increased expression of PTGS2 protein	PMID:17222177
increases expression	EXP		6480464	CTD	Quartz results in increased expression of PTGS2 protein	PMID:17222177