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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3031
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad2
Name: SMAD family member 2
Acc ID: CHEBI:46680
Term: serpentine asbestos
Definition: null
Chemical ID: MESH:D017632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad2affects localizationISOSMAD2 (Homo sapiens)6480464CTDAsbestos, Serpentine affects the localization of SMAD2 protein modified formPMID:26685284
Smad2increases phosphorylationISOSMAD2 (Homo sapiens)6480464CTDAsbestos, Serpentine results in increased phosphorylation of SMAD2 proteinPMID:30609805
Smad2multiple interactionsISOSMAD2 (Homo sapiens)6480464CTD[Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in increased expression of SMAD2 mRNA; [Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in increased phosphorylation of SMAD2 proteinPMID:25358858
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