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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736621 Species: Mus musculus RGD Object: Gene Symbol: COX1 Name: cytochrome c oxidase I, mitochondrial

Acc ID: CHEBI:4659 Term: disulfiram Definition: An organic disulfide that has formula C10H20N2S4. CasRN: 97-77-8 Chemical ID: MESH:D004221

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects activity	ISO	RGD:621871	6480464	CTD	Disulfiram affects the activity of COX1 protein	PMID:17936468
affects expression	ISO	RGD:621871	6480464	CTD	Disulfiram affects the expression of COX1 mRNA	PMID:17936468