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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735171
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tlr3
Name: toll-like receptor 3
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr3increases expressionISOTLR3 (Homo sapiens)6480464CTDFluorouracil results in increased expression of TLR3 mRNAPMID:18779317 PMID:20367642
Tlr3multiple interactionsISOTLR3 (Homo sapiens)6480464CTDTP53 protein affects the reaction [Fluorouracil results in increased expression of TLR3 mRNA]PMID:18779317
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