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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733191 Species: Mus musculus RGD Object: Gene Symbol: Hspa4 Name: heat shock protein 4

Acc ID: CHEBI:46345 Term: 5-fluorouracil Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth. CasRN: 51-21-8 Chemical ID: MESH:D005472

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:733190	6480464	CTD	Fluorouracil results in decreased expression of HSPA4 protein	PMID:15352031
affects response to substance	ISO	RGD:733190	6480464	CTD	HSPA4 protein affects the susceptibility to Fluorouracil	PMID:15352031