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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3185 Species: Rattus norvegicus RGD Object: Gene Symbol: Nos2 Name: nitric oxide synthase 2, inducible

Acc ID: CHEBI:46345 Term: 5-fluorouracil Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth. CasRN: 51-21-8 Chemical ID: MESH:D005472

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10996	6480464	CTD	Fluorouracil results in increased expression of and results in increased activity of NOS2 protein	PMID:18069768
increases expression	ISO	RGD:730951	6480464	CTD	Fluorouracil results in increased expression of NOS2 protein	PMID:12150722
multiple interactions	ISO	RGD:10996	6480464	CTD	Fluorouracil inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] Fluorouracil inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]	PMID:16724238