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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2944
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Junb
Name: JunB proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junbincreases expressionISOJUNB (Homo sapiens)6480464CTDFluorouracil results in increased expression of JUNB mRNAPMID:16557594
Junbmultiple interactionsISOJUNB (Homo sapiens)6480464CTDJUNB results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine]PMID:18678097
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