GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Erbb2 | affects expression | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | Fluorouracil affects the expression of ERBB2 mRNA | PMID:15205334 | Erbb2 | affects response to substance | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | ERBB2 mRNA alternative form affects the susceptibility to Fluorouracil | PMID:36639866 | Erbb2 | decreases response to substance | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | ERBB2 mRNA results in decreased susceptibility to Fluorouracil; ERBB2 results in decreased susceptibility to Fluorouracil | PMID:18337622 PMID:21712253 | Erbb2 | multiple interactions | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Fluorouracil]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Fluorouracil]; [Apigenin co-treated with Fluorouracil] results in decreased expression of ERBB2 protein; [Cisplatin co-treated with Fluorouracil] results in decreased expression of ERBB2 mRNA; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Fluorouracil; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Fluorouracil]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased expression of and results in decreased activity of ERBB2 protein]; ERBB2 protein affects the susceptibility to [Cyclophosphamide co-treated with pirarubicin co-treated with Fluorouracil]; ERBB2 protein affects the susceptibility to [Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]; ERBB2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; Fluorouracil results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein | PMID:15737843 PMID:15940066 PMID:16446318 PMID:16682728 PMID:17918158 PMID:19885610 PMID:21712253 PMID:9816327 | |
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