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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2225 Species: Rattus norvegicus RGD Object: Gene Symbol: Btg2 Name: BTG family, member 2

Acc ID: CHEBI:46345 Term: 5-fluorouracil Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth. CasRN: 51-21-8 Chemical ID: MESH:D005472

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:69157	6480464	CTD	Fluorouracil results in increased expression of BTG2 mRNA	PMID:17982676
multiple interactions	ISO	RGD:69157	6480464	CTD	TP53 protein affects the reaction [Fluorouracil results in increased expression of BTG2 mRNA]	PMID:15016801
multiple interactions	ISO	RGD:69157	6480464	CTD	TP53 protein promotes the reaction [Fluorouracil results in increased expression of BTG2 mRNA]	PMID:17982676