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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308982 Species: Rattus norvegicus RGD Object: Gene Symbol: Prkdc Name: protein kinase, DNA activated, catalytic polypeptide

Acc ID: CHEBI:46345 Term: 5-fluorouracil Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth. CasRN: 51-21-8 Chemical ID: MESH:D005472

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1319072	6480464	CTD	TP53 protein affects the reaction [Fluorouracil results in decreased expression of PRKDC mRNA]	PMID:15016801
multiple interactions	ISO	RGD:1319072	6480464	CTD	PRKDC mRNA results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]	PMID:18546291