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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730944 Species: Homo sapiens RGD Object: Gene Symbol: ABCB11 Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11

Acc ID: CHEBI:46195 Term: paracetamol Definition: A derivative of phenol which has an acetamido substituent located para to the phenolic -OH group. CasRN: 103-90-2 Chemical ID: MESH:D000082

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:619930	6480464	CTD	Acetaminophen results in decreased expression of ABCB11 mRNA	PMID:17522070
affects expression	ISO	RGD:730945	6480464	CTD	Acetaminophen affects the expression of ABCB11 mRNA	PMID:17562736
multiple interactions	ISO	RGD:730945	6480464	CTD	[Acetaminophen co-treated with Sodium Chloride] results in decreased expression of ABCB11 mRNA	PMID:17934960
decreases expression	EXP		6480464	CTD	Acetaminophen results in decreased expression of ABCB11 mRNA	PMID:21420995