GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr0b2 | decreases expression | EXP | | 6480464 | CTD | Acetaminophen results in decreased expression of NR0B2 mRNA | PMID:33387578 | Nr0b2 | affects expression | ISO | Nr0b2 (Mus musculus) | 6480464 | CTD | Acetaminophen affects the expression of NR0B2 mRNA | PMID:17562736 | Nr0b2 | affects response to substance | ISO | Nr0b2 (Mus musculus) | 6480464 | CTD | NR0B2 protein affects the susceptibility to Acetaminophen | PMID:29943110 | Nr0b2 | decreases expression | ISO | Nr0b2 (Mus musculus) | 6480464 | CTD | Acetaminophen results in decreased expression of NR0B2 mRNA | PMID:29943110 | Nr0b2 | multiple interactions | ISO | NR0B2 (Homo sapiens) | 6480464 | CTD | [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of NR0B2 mRNA; SHP protein inhibits the reaction [Acetaminophen results in increased expression of GCLM protein]; SHP protein inhibits the reaction [Acetaminophen results in increased expression of NFE2L2 protein]; SHP protein inhibits the reaction [Acetaminophen results in increased expression of NQO1 protein] | PMID:33819548 PMID:37792503 | Nr0b2 | multiple interactions | ISO | Nr0b2 (Mus musculus) | 6480464 | CTD | [Clofibrate co-treated with Acetaminophen] affects the expression of NR0B2 mRNA; GADD45B protein affects the reaction [NR0B2 protein affects the reaction [Acetaminophen results in increased expression of GPT protein]]; NR0B2 protein affects the reaction [Acetaminophen results in increased expression of GADD45B mRNA]; NR0B2 protein affects the reaction [Acetaminophen results in increased expression of GPT protein]; NR0B2 protein affects the reaction [Acetaminophen results in increased phosphorylation of MAP2K4 protein]; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NR0B2 mRNA] | PMID:17585979 PMID:29943110 | |
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