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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr0b2decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of NR0B2 mRNAPMID:33387578
Nr0b2affects expressionISONr0b2 (Mus musculus)6480464CTDAcetaminophen affects the expression of NR0B2 mRNAPMID:17562736
Nr0b2affects response to substanceISONr0b2 (Mus musculus)6480464CTDNR0B2 protein affects the susceptibility to AcetaminophenPMID:29943110
Nr0b2decreases expressionISONr0b2 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of NR0B2 mRNAPMID:29943110
Nr0b2multiple interactionsISONR0B2 (Homo sapiens)6480464CTD[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of NR0B2 mRNA; SHP protein inhibits the reaction [Acetaminophen results in increased expression of GCLM protein]; SHP protein inhibits the reaction [Acetaminophen results in increased expression of NFE2L2 protein]; SHP protein inhibits the reaction [Acetaminophen results in increased expression of NQO1 protein]PMID:33819548 PMID:37792503
Nr0b2multiple interactionsISONr0b2 (Mus musculus)6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of NR0B2 mRNA; GADD45B protein affects the reaction [NR0B2 protein affects the reaction [Acetaminophen results in increased expression of GPT protein]]; NR0B2 protein affects the reaction [Acetaminophen results in increased expression of GADD45B mRNA]; NR0B2 protein affects the reaction [Acetaminophen results in increased expression of GPT protein]; NR0B2 protein affects the reaction [Acetaminophen results in increased phosphorylation of MAP2K4 protein]; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NR0B2 mRNA]PMID:17585979 PMID:29943110
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