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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620525
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mcl1
Name: MCL1 apoptosis regulator, BCL2 family member
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mcl1affects expressionISOMCL1 (Homo sapiens)6480464CTDAcetaminophen affects the expression of MCL1 mRNAPMID:11896290
Mcl1affects expressionISOMcl1 (Mus musculus)6480464CTDAcetaminophen affects the expression of MCL1 mRNAPMID:17562736
Mcl1decreases expressionISOMcl1 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of MCL1 proteinPMID:25752611
Mcl1increases expressionISOMcl1 (Mus musculus)6480464CTDAcetaminophen results in increased expression of MCL1 mRNA; Acetaminophen results in increased expression of MCL1 proteinPMID:18544908 PMID:25752611
Mcl1multiple interactionsISOMcl1 (Mus musculus)6480464CTDAcetaminophen promotes the reaction [PRKN gene mutant form results in increased expression of MCL1 protein]; Bortezomib inhibits the reaction [Acetaminophen results in decreased expression of MCL1 protein]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of MCL1 mRNA]; PRKN mutant form inhibits the reaction [Acetaminophen results in increased expression of MCL1 protein]PMID:18700144 PMID:25752611
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