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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619757
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acox1
Name: acyl-CoA oxidase 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acox1decreases activityEXP 6480464CTDAcetaminophen results in decreased activity of ACOX1 proteinPMID:25858767
Acox1affects expressionISOAcox1 (Mus musculus)6480464CTDAcetaminophen affects the expression of ACOX1 mRNAPMID:17562736
Acox1decreases expressionISOACOX1 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of ACOX1 mRNAPMID:21420995 PMID:29067470
Acox1increases expressionISOAcox1 (Mus musculus)6480464CTDAcetaminophen results in increased expression of ACOX1 mRNA; Acetaminophen results in increased expression of ACOX1 proteinPMID:21329376 PMID:33271250
Acox1multiple interactionsISOAcox1 (Mus musculus)6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of ACOX1 mRNA; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ACOX1 mRNA]PMID:17585979
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