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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53affects expressionEXP 6480464CTDAcetaminophen affects the expression of TP53 mRNAPMID:16701773
Tp53decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of TP53 mRNA; Acetaminophen results in decreased expression of TP53 proteinPMID:16330492 PMID:33387578
Tp53increases activityEXP 6480464CTDAcetaminophen results in increased activity of TP53 proteinPMID:25858767
Tp53increases expressionEXP 6480464CTDAcetaminophen results in increased expression of TP53 mRNAPMID:21807079
Tp53increases phosphorylationEXP 6480464CTDAcetaminophen results in increased phosphorylation of TP53 proteinPMID:16330492
Tp53multiple interactionsEXP 6480464CTDAcetaminophen promotes the reaction [MDM2 protein binds to TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Acetaminophen results in increased degradation of TP53 protein]; Chlormethiazole inhibits the reaction [Acetaminophen results in increased degradation of TP53 protein]; Etoposide promotes the reaction [Acetaminophen results in increased phosphorylation of TP53 protein]; Fluorouracil promotes the reaction [Acetaminophen results in increased phosphorylation of TP53 protein]; lactacystin inhibits the reaction [Acetaminophen results in increased degradation of TP53 protein]PMID:16330492
Tp53decreases expressionISOTP53 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of TP53 mRNAPMID:21420995 PMID:25704631
Tp53increases expressionISOTrp53 (Mus musculus)6480464CTDAcetaminophen results in increased expression of TRP53 proteinPMID:11461765 PMID:22939915 PMID:25956474
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTD4-aminobenzamide promotes the reaction [Acetaminophen results in decreased expression of TRP53 protein]; Acetaminophen results in increased expression of and results in increased phosphorylation of TRP53 protein; dioscin inhibits the reaction [Acetaminophen results in increased expression of TRP53 protein]; NAD promotes the reaction [Acetaminophen results in decreased expression of TRP53 protein]; resveratrol inhibits the reaction [Acetaminophen results in increased expression of TRP53 protein]; schizandrol B inhibits the reaction [Acetaminophen results in increased activity of TRP53 protein]; schizandrol B inhibits the reaction [Acetaminophen results in increased expression of and results in increased phosphorylation of TRP53 protein]PMID:11461765 PMID:22939915 PMID:25319358 PMID:25956474
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