Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects expressionEXP 6480464CTDAcetaminophen affects the expression of CYP1A2 mRNAPMID:11245408 PMID:17366322
Cyp1a2decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of CYP1A2 mRNAPMID:12969438 PMID:21807079
Cyp1a2increases chemical synthesisEXP 6480464CTDCYP1A2 protein results in increased chemical synthesis of AcetaminophenPMID:28438436
Cyp1a2increases expressionEXP 6480464CTDAcetaminophen results in increased expression of CYP1A2 proteinPMID:18798224
Cyp1a2multiple interactionsEXP 6480464CTD[CYP1A2 protein results in increased metabolism of Phenacetin] which results in increased chemical synthesis of Acetaminophen; [Dextran Sulfate results in decreased activity of CYP1A2 protein] which results in decreased chemical synthesis of Acetaminophen; [EGF protein co-treated with HGF protein] promotes the reaction [Acetaminophen results in decreased expression of CYP1A2 mRNA]; Acetaminophen inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Choline deficiency inhibits the reaction [Acetaminophen results in increased expression of CYP1A2 protein]PMID:12969438 PMID:18493746 PMID:18798224 PMID:28438436
Cyp1a2affects expressionISOCyp1a2 (Mus musculus)6480464CTDAcetaminophen affects the expression of CYP1A2 mRNAPMID:17562736
Cyp1a2decreases expressionISOCyp1a2 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of CYP1A2 mRNA; Acetaminophen results in decreased expression of CYP1A2 proteinPMID:15576447 PMID:16611625 PMID:21329376
Cyp1a2decreases expressionISOCYP1A2 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of CYP1A2 mRNAPMID:32112222
Cyp1a2increases abundanceISOCyp1a2 (Mus musculus)6480464CTDCYP1A2 protein results in increased abundance of AcetaminophenPMID:10445756
Cyp1a2increases chemical synthesisISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased chemical synthesis of AcetaminophenPMID:12401345 PMID:15155557 PMID:21915887 PMID:23850985 PMID:27939613 PMID:31706005
Cyp1a2increases expressionISOCyp1a2 (Mus musculus)6480464CTDAcetaminophen results in increased expression of CYP1A2 mRNA; Acetaminophen results in increased expression of CYP1A2 proteinPMID:12958197 PMID:14978233 PMID:16141365 PMID:19002106
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of CYP1A2 mRNAPMID:33811995
Cyp1a2increases metabolic processingISOCyp1a2 (Mus musculus)6480464CTDCYP1A2 protein results in increased metabolism of AcetaminophenPMID:10977129 PMID:19002106
Cyp1a2increases metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 results in increased metabolism of AcetaminophenPMID:20566340
Cyp1a2increases oxidationISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased oxidation of AcetaminophenPMID:10811468
Cyp1a2increases response to substanceISOCyp1a2 (Mus musculus)6480464CTDCYP1A2 protein results in increased susceptibility to AcetaminophenPMID:16141365 PMID:16557553 PMID:19679878
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of CYP1A2 mRNA; [CYP1A2 protein results in increased metabolism of Phenacetin] which results in increased chemical synthesis of Acetaminophen; [IL33 protein affects the susceptibility to Acetaminophen] which affects the expression of CYP1A2 mRNA; CYP1A2 protein affects the metabolism of and results in decreased abundance of Acetaminophen; CYP1A2 protein results in increased metabolism of and affects the susceptibility to Acetaminophen; IL1A protein inhibits the reaction [Acetaminophen results in increased expression of CYP1A2 protein]; NR1I2 protein affects the reaction [Acetaminophen results in increased expression of CYP1A2 mRNA]; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CYP1A2 mRNA]; PPARA protein affects the reaction [Acetaminophen results in increased expression of CYP1A2 mRNA]; RXRA protein promotes the reaction [Acetaminophen results in increased expression of CYP1A2 mRNA]; SLC13A1 protein affects the reaction [Acetaminophen results in increased expression of CYP1A2 mRNA]; YAP1 gene mutant form promotes the reaction [Acetaminophen results in increased expression of CYP1A2 mRNA]PMID:11376689 PMID:12958197 PMID:14978233 PMID:16141365 PMID:16729303 PMID:17585979 PMID:19002106 PMID:19679878 PMID:30503582 PMID:33887374 PMID:34546377
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[CYP1A2 protein results in increased metabolism of Phenacetin] which results in increased chemical synthesis of Acetaminophen; [CYP2E1 protein co-treated with CYP1A2 protein] results in increased susceptibility to Acetaminophen; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of Acetaminophen]; furafylline inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of Acetaminophen]; GSTM1 protein inhibits the reaction [[CYP2E1 protein co-treated with CYP1A2 protein] results in increased susceptibility to Acetaminophen]; obeticholic acid inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of Acetaminophen]; Oxygen deficiency inhibits the reaction [Acetaminophen results in increased expression of CYP1A2 mRNA]PMID:19135037 PMID:21915887 PMID:27939613 PMID:28762043 PMID:31706005 PMID:33811995 PMID:35366062 PMID:35748891
Go Back to source page   Continue to Ontology report