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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2280
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cav1
Name: caveolin 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cav1decreases expressionISOCav1 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of CAV1 proteinPMID:20100502
Cav1decreases expressionISOCAV1 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of CAV1 mRNAPMID:21420995 PMID:29067470
Cav1increases response to substanceISOCav1 (Mus musculus)6480464CTDCAV1 results in increased susceptibility to AcetaminophenPMID:20100502
Cav1multiple interactionsISOCav1 (Mus musculus)6480464CTDCAV1 affects the reaction [Acetaminophen results in increased expression of BIRC5 protein]; CAV1 affects the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; CAV1 affects the reaction [Acetaminophen results in increased expression of PCNA protein]; CAV1 affects the reaction [Acetaminophen results in increased expression of PTGS2 protein]PMID:20100502
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