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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200 Species: Rattus norvegicus RGD Object: Gene Symbol: Bcl2l1 Name: Bcl2-like 1

Acc ID: CHEBI:46195 Term: paracetamol Definition: A derivative of phenol which has an acetamido substituent located para to the phenolic -OH group. CasRN: 103-90-2 Chemical ID: MESH:D000082

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:1552009	6480464	CTD	Acetaminophen results in decreased expression of BCL2L1 protein	PMID:18467506 PMID:11461765 PMID:15673306
decreases expression	ISO	RGD:1552009	6480464	CTD	Acetaminophen results in decreased expression of BCL2L1 protein	PMID:18467506 PMID:15673306 PMID:11461765
affects expression	ISO	RGD:735516	6480464	CTD	Acetaminophen affects the expression of BCL2L1 mRNA	PMID:11896290
multiple interactions	ISO	RGD:1552009	6480464	CTD	4-aminobenzamide inhibits the reaction [Acetaminophen results in decreased expression of BCL2L1 protein] NAD inhibits the reaction [Acetaminophen results in decreased expression of BCL2L1 protein]	PMID:11461765
multiple interactions	ISO	RGD:1552009	6480464	CTD	Acetaminophen affects the expression of and affects the phosphorylation of BCL2L1 protein	PMID:10663392
affects expression	ISO	RGD:1552009	6480464	CTD	Acetaminophen affects the expression of BCL2L1 mRNA	PMID:17562736
decreases expression	ISO	RGD:1552009	6480464	CTD	Acetaminophen results in decreased expression of BCL2L1 protein	PMID:15673306 PMID:11461765 PMID:18467506
increases expression	ISO	RGD:1552009	6480464	CTD	Acetaminophen results in increased expression of BCL2L1 mRNA	PMID:11264010
multiple interactions	ISO	RGD:1552009	6480464	CTD	lactacystin inhibits the reaction [Acetaminophen results in decreased expression of BCL2L1 protein]	PMID:15673306
multiple interactions	ISO	RGD:1552009	6480464	CTD	KITL protein inhibits the reaction [Acetaminophen results in decreased expression of BCL2L1 protein]	PMID:18467506
affects expression	EXP		6480464	CTD	Acetaminophen affects the expression of BCL2L1 mRNA	PMID:19784758
decreases expression	EXP		6480464	CTD	Acetaminophen results in decreased expression of BCL2L1 mRNA	PMID:19784758
increases expression	EXP		6480464	CTD	Acetaminophen results in increased expression of BCL2L1 mRNA	PMID:19784758
increases expression	EXP		6480464	CTD	Acetaminophen results in increased expression of BCL2L1 protein modified form	PMID:20166895
multiple interactions	EXP		6480464	CTD	anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Acetaminophen results in increased expression of BCL2L1 protein modified form] Taurine inhibits the reaction [Acetaminophen results in increased expression of BCL2L1 protein modified form]	PMID:20166895
decreases expression	ISO	RGD:1552009	6480464	CTD	Acetaminophen results in decreased expression of BCL2L1 protein	PMID:11461765 PMID:18467506 PMID:15673306
decreases expression	ISO	RGD:735516	6480464	CTD	Acetaminophen results in decreased expression of BCL2L1 mRNA	PMID:21420995
decreases expression	ISO	RGD:1552009	6480464	CTD	Acetaminophen results in decreased expression of BCL2L1 protein	PMID:11461765 PMID:15673306 PMID:18467506