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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axdecreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of H2AX mRNA; Acetaminophen results in decreased expression of H2AX proteinPMID:26011634 PMID:33387578
H2axaffects expressionISOH2AX (Homo sapiens)6480464CTDAcetaminophen affects the expression of H2AX mRNAPMID:25458485
H2axaffects expressionISOH2ax (Mus musculus)6480464CTDAcetaminophen affects the expression of H2AX mRNAPMID:17562736
H2axincreases expressionISOH2AX (Homo sapiens)6480464CTDAcetaminophen results in increased expression of H2AX mRNA; Acetaminophen results in increased expression of H2AX proteinPMID:21420995 PMID:22230336 PMID:33971260
H2axincreases expressionISOH2ax (Mus musculus)6480464CTDAcetaminophen results in increased expression of H2AX protein modified formPMID:29540258
H2axmultiple interactionsISOH2AX (Homo sapiens)6480464CTD2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide promotes the reaction [Acetaminophen results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of H2AX protein]; Caffeine promotes the reaction [Acetaminophen results in increased expression of H2AX protein]PMID:33971260
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