GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | H2ax | decreases expression | EXP | | 6480464 | CTD | Acetaminophen results in decreased expression of H2AX mRNA; Acetaminophen results in decreased expression of H2AX protein | PMID:26011634 PMID:33387578 | H2ax | affects expression | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Acetaminophen affects the expression of H2AX mRNA | PMID:25458485 | H2ax | affects expression | ISO | H2ax (Mus musculus) | 6480464 | CTD | Acetaminophen affects the expression of H2AX mRNA | PMID:17562736 | H2ax | increases expression | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Acetaminophen results in increased expression of H2AX mRNA; Acetaminophen results in increased expression of H2AX protein | PMID:21420995 PMID:22230336 PMID:33971260 | H2ax | increases expression | ISO | H2ax (Mus musculus) | 6480464 | CTD | Acetaminophen results in increased expression of H2AX protein modified form | PMID:29540258 | H2ax | multiple interactions | ISO | H2AX (Homo sapiens) | 6480464 | CTD | 2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide promotes the reaction [Acetaminophen results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of H2AX protein]; Caffeine promotes the reaction [Acetaminophen results in increased expression of H2AX protein] | PMID:33971260 | |
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