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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:46024
Term: trichostatin A
Definition: A trichostatin that has formula 302.36826.
Chemical ID: MESH:C012589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1increases expressionISOTGFB1 (Homo sapiens)6480464CTDtrichostatin A results in increased expression of TGFB1 mRNAPMID:16365456 PMID:25280005
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTDtrichostatin A promotes the reaction [IL1B protein results in increased expression of TGFB1 mRNA]PMID:16365456
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTDtrichostatin A inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; trichostatin A inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]PMID:27396813
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