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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:45980
Term: tacrine
Definition: A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Chemical ID: MESH:D013619
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects metabolic processingEXP 6480464CTDCYP1A2 protein affects the metabolism of TacrinePMID:15258105
Cyp1a2decreases activityEXP 6480464CTDTacrine results in decreased activity of CYP1A2 proteinPMID:15258105
Cyp1a2multiple interactionsEXP 6480464CTDTacrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]PMID:18493746
Cyp1a2increases metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased metabolism of TacrinePMID:7946932
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTDChloroquine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; Enoxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; NADP promotes the reaction [Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]]; NADP promotes the reaction [Enoxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]]; Tacrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]PMID:18493746 PMID:7946932
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