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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:45924
Term: trimethoprim
Definition: An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Chemical ID: MESH:D014295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDTrimethoprim results in decreased activity of CYP1A2 proteinPMID:26599973
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[Trimethoprim results in decreased activity of CYP1A2 protein] which results in decreased metabolism of AmodiaquinePMID:26599973
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