• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735711 Species: Homo sapiens RGD Object: Gene Symbol: CYP1A2 Name: cytochrome P450, family 1, subfamily A, polypeptide 2

Acc ID: CHEBI:45863 Term: paclitaxel Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark. CasRN: 33069-62-4 Chemical ID: MESH:D017239

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:2459	6480464	CTD	Paclitaxel results in increased expression of CYP1A2 mRNA	PMID:15585946
decreases activity	EXP		6480464	CTD	Paclitaxel results in decreased activity of CYP1A2 protein	PMID:19909766