• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731438 Species: Homo sapiens RGD Object: Gene Symbol: MYC Name: v-myc myelocytomatosis viral oncogene homolog (avian)

Acc ID: CHEBI:45863 Term: paclitaxel Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark. CasRN: 33069-62-4 Chemical ID: MESH:D017239

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Curcumin inhibits the reaction [Paclitaxel results in increased expression of MYC protein]	PMID:16243823
decreases expression	EXP		6480464	CTD	Paclitaxel results in decreased expression of MYC protein	PMID:15907983
affects response to substance	EXP		6480464	CTD	MYC protein affects the susceptibility to Paclitaxel	PMID:18802399