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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620160 Species: Rattus norvegicus RGD Object: Gene Symbol: Bid Name: BH3 interacting domain death agonist

Acc ID: CHEBI:45863 Term: paclitaxel Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark. CasRN: 33069-62-4 Chemical ID: MESH:D017239

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1346183	6480464	CTD	Paclitaxel results in increased expression of BID protein	PMID:14749477
increases cleavage	ISO	RGD:1346183	6480464	CTD	Paclitaxel results in increased cleavage of BID protein	PMID:18098270
multiple interactions	ISO	RGD:1346183	6480464	CTD	[Tretinoin co-treated with Paclitaxel] results in increased cleavage of BID protein	PMID:18098270