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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases exportISOSOD2 (Homo sapiens)6480464CTDSOD2 protein results in decreased export of PaclitaxelPMID:32201199
Sod2decreases response to substanceISOSOD2 (Homo sapiens)6480464CTDSOD2 protein results in decreased susceptibility to PaclitaxelPMID:18594523 PMID:32201199
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDPaclitaxel results in increased expression of SOD2 mRNAPMID:9852137
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; [benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP9 protein] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; [MAP2K1 protein affects the activity of [MAPK1 protein co-treated with MAPK3 protein]] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; Acetylcysteine affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; bisindolylmaleimide I inhibits the reaction [Paclitaxel results in increased expression of SOD2 mRNA]; calphostin C inhibits the reaction [Paclitaxel results in increased expression of SOD2 mRNA]; Cycloheximide promotes the reaction [Paclitaxel results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Paclitaxel results in increased expression of SOD2 mRNA]; Glutathione affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; SOD2 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK1 protein]; SOD2 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Paclitaxel results in increased expression of SOD2 mRNA]PMID:18594523 PMID:9852137
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