GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sod2 | decreases export | ISO | SOD2 (Homo sapiens) | 6480464 | CTD | SOD2 protein results in decreased export of Paclitaxel | PMID:32201199 | Sod2 | decreases response to substance | ISO | SOD2 (Homo sapiens) | 6480464 | CTD | SOD2 protein results in decreased susceptibility to Paclitaxel | PMID:18594523 PMID:32201199 | Sod2 | increases expression | ISO | SOD2 (Homo sapiens) | 6480464 | CTD | Paclitaxel results in increased expression of SOD2 mRNA | PMID:9852137 | Sod2 | multiple interactions | ISO | SOD2 (Homo sapiens) | 6480464 | CTD | [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; [benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP9 protein] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; [MAP2K1 protein affects the activity of [MAPK1 protein co-treated with MAPK3 protein]] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; Acetylcysteine affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; bisindolylmaleimide I inhibits the reaction [Paclitaxel results in increased expression of SOD2 mRNA]; calphostin C inhibits the reaction [Paclitaxel results in increased expression of SOD2 mRNA]; Cycloheximide promotes the reaction [Paclitaxel results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Paclitaxel results in increased expression of SOD2 mRNA]; Glutathione affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; SOD2 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK1 protein]; SOD2 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Paclitaxel results in increased expression of SOD2 mRNA] | PMID:18594523 PMID:9852137 | |
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