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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619977
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac3
Name: histone deacetylase 3
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac3decreases activityISOHDAC3 (Homo sapiens)6480464CTDvorinostat results in decreased activity of HDAC3 proteinPMID:15930892
Hdac3decreases expressionISOHDAC3 (Homo sapiens)6480464CTDvorinostat results in decreased expression of HDAC3 proteinPMID:18850582
Hdac3multiple interactionsISOHDAC3 (Homo sapiens)6480464CTDvorinostat results in decreased activity of [HDAC3 protein binds to NCOR2 protein]PMID:21548582
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