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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3534
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rara
Name: retinoic acid receptor, alpha
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raradecreases expressionISORARA (Homo sapiens)6480464CTDvorinostat results in decreased expression of RARA protein mutant formPMID:27189198
Raraincreases expressionISORARA (Homo sapiens)6480464CTDvorinostat results in increased expression of RARA mRNAPMID:17417771
Raramultiple interactionsISORARA (Homo sapiens)6480464CTD[vorinostat co-treated with arsenic trioxide] results in decreased expression of RARA protein mutant form; decitabine promotes the reaction [vorinostat results in increased expression of RARA mRNA]PMID:17417771 PMID:27189198
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