• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730822 Species: Mus musculus RGD Object: Gene Symbol: Mmp2 Name: matrix metallopeptidase 2

Acc ID: CHEBI:45713 Term: trans-resveratrol Definition: A resveratrol that has formula C14H12O3. CasRN: 501-36-0 Chemical ID: MESH:C059514

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:730821	6480464	CTD	resveratrol results in decreased activity of MMP2 protein	PMID:17935668 PMID:16317118
multiple interactions	ISO	RGD:730821	6480464	CTD	resveratrol results in decreased expression of and results in decreased activity of MMP2 protein	PMID:17049120
decreases expression	ISO	RGD:730821	6480464	CTD	resveratrol results in decreased expression of MMP2 protein	PMID:16084059
decreases expression	ISO	RGD:730821	6480464	CTD	resveratrol results in decreased expression of MMP2 mRNA	PMID:17935668 PMID:16084059
increases secretion	ISO	RGD:730821	6480464	CTD	resveratrol results in increased secretion of MMP2 protein	PMID:22314268
multiple interactions	ISO	RGD:730821	6480464	CTD	resveratrol inhibits the reaction [HMOX1 protein results in increased expression of MMP2 protein]	PMID:20461740
decreases secretion	ISO	RGD:730821	6480464	CTD	resveratrol results in decreased secretion of MMP2 protein	PMID:10733549 PMID:18674879 PMID:20677551
multiple interactions	ISO	RGD:730821	6480464	CTD	[SU 1498 results in decreased activity of KDR protein] inhibits the reaction [resveratrol results in increased secretion of MMP2 protein]	PMID:22314268
decreases activity	ISO	RGD:730821	6480464	CTD	resveratrol results in decreased activity of MMP2 protein	PMID:16317118 PMID:17935668
decreases expression	ISO	RGD:730821	6480464	CTD	resveratrol results in decreased expression of MMP2 mRNA	PMID:16084059 PMID:17935668
multiple interactions	EXP		6480464	CTD	resveratrol inhibits the reaction [Calcium Chloride results in increased activity of MMP2 protein]	PMID:21530968
increases expression	EXP		6480464	CTD	resveratrol results in increased expression of MMP2 protein	PMID:18572362
multiple interactions	ISO	RGD:730821	6480464	CTD	resveratrol results in decreased expression of and results in decreased activity of MMP2 protein	PMID:17049120 PMID:18674879
decreases expression	ISO	RGD:730821	6480464	CTD	resveratrol results in decreased expression of MMP2 protein	PMID:16084059 PMID:21209944
decreases secretion	ISO	RGD:730821	6480464	CTD	resveratrol results in decreased secretion of MMP2 protein	PMID:20677551
decreases expression	ISO	RGD:730821	6480464	CTD	resveratrol results in decreased expression of MMP2	PMID:21238464
decreases secretion	ISO	RGD:730821	6480464	CTD	resveratrol results in decreased secretion of MMP2 protein	PMID:18674879 PMID:20677551