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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995 Species: Rattus norvegicus RGD Object: Gene Symbol: Pten Name: phosphatase and tensin homolog

Acc ID: CHEBI:45713 Term: trans-resveratrol Definition: A resveratrol that has formula C14H12O3. CasRN: 501-36-0 Chemical ID: MESH:C059514

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:69119	6480464	CTD	resveratrol results in increased expression of PTEN protein	PMID:15829497 PMID:20637737 PMID:20729295 PMID:21168265 PMID:21980390
increases expression	ISO	RGD:69119	6480464	CTD	resveratrol results in increased expression of PTEN mRNA resveratrol results in increased expression of PTEN protein	PMID:15829497
increases expression	ISO	RGD:69119	6480464	CTD	resveratrol results in increased expression of PTEN protein	PMID:15829497 PMID:21980390
multiple interactions	ISO	RGD:69119	6480464	CTD	PTEN protein promotes the reaction [resveratrol results in decreased phosphorylation of MTOR protein]	PMID:21168265
multiple interactions	ISO	RGD:69119	6480464	CTD	[resveratrol results in decreased activity of AR protein] which results in increased expression of PTEN mRNA	PMID:20729295
increases expression	ISO	RGD:69119	6480464	CTD	resveratrol results in increased expression of PTEN protein	PMID:15829497 PMID:20729295 PMID:21168265 PMID:21980390
increases phosphorylation	ISO	RGD:62287	6480464	CTD	resveratrol results in increased phosphorylation of PTEN protein	PMID:22363816