• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2670 Species: Rattus norvegicus RGD Object: Gene Symbol: Gck Name: glucokinase

Acc ID: CHEBI:45713 Term: trans-resveratrol Definition: A resveratrol that has formula C14H12O3. CasRN: 501-36-0 Chemical ID: MESH:C059514

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	resveratrol inhibits the reaction [INS1 protein results in increased expression of GCK mRNA]	PMID:16626303
multiple interactions	ISO	RGD:735697	6480464	CTD	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of GCK mRNA]]	PMID:21163946
increases expression	ISO	RGD:735697	6480464	CTD	resveratrol results in increased expression of GCK mRNA	PMID:21163946
multiple interactions	EXP		6480464	CTD	FOXO1 protein promotes the reaction [resveratrol results in decreased activity of GCK protein] FOXO1 protein promotes the reaction [resveratrol inhibits the reaction [HNF4A protein binds to GCK promoter]] FOXO1 protein promotes the reaction [resveratrol results in decreased expression of GCK mRNA] resveratrol affects the reaction [HNF4A protein binds to GCK promoter] [resveratrol promotes the reaction [FOXO1 protein binds to HNF4A protein]] which results in decreased expression of GCK mRNA resveratrol promotes the reaction [FOXO1 protein binds to GCK promoter]	PMID:19740748
decreases activity	EXP		6480464	CTD	resveratrol results in decreased activity of GCK protein	PMID:19740748
decreases expression	EXP		6480464	CTD	resveratrol results in decreased expression of GCK mRNA resveratrol results in decreased expression of GCK protein	PMID:19740748