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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347509 Species: Homo sapiens RGD Object: Gene Symbol: CFLAR Name: CASP8 and FADD-like apoptosis regulator

Acc ID: CHEBI:45713 Term: trans-resveratrol Definition: A resveratrol that has formula C14H12O3. CasRN: 501-36-0 Chemical ID: MESH:C059514

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:731977	6480464	CTD	resveratrol results in decreased expression of CFLAR protein	PMID:17872969
increases expression	ISO	RGD:731977	6480464	CTD	resveratrol results in increased expression of CFLAR mRNA	PMID:16081268
decreases expression	EXP		6480464	CTD	resveratrol results in decreased expression of CFLAR protein	PMID:20097879
multiple interactions	EXP		6480464	CTD	TNFSF10 protein promotes the reaction [resveratrol results in decreased expression of CFLAR protein]	PMID:20097879
decreases cleavage	EXP		6480464	CTD	resveratrol results in decreased cleavage of CFLAR protein	PMID:18222423