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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962 Species: Homo sapiens RGD Object: Gene Symbol: CYP3A4 Name: cytochrome P450, family 3, subfamily A, polypeptide 4

Acc ID: CHEBI:45367 Term: rifabutin Definition: A rifamycin that has formula C46H62N4O11. CasRN: 72559-06-9 Chemical ID: MESH:D017828

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Rifabutin results in increased expression of CYP3A4 mRNA	PMID:16837568
multiple interactions	EXP		6480464	CTD	AADAC mRNA affects the reaction [Rifabutin results in increased expression of CYP3A4 mRNA]	PMID:21856291
increases expression	EXP		6480464	CTD	Rifabutin results in increased expression of CYP3A4 mRNA	PMID:16837568 PMID:21856291