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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733892 Species: Mus musculus RGD Object: Gene Symbol: Gsk3b Name: glycogen synthase kinase 3 beta

Acc ID: CHEBI:4495 Term: diazoxide Definition: A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies. CasRN: 7683-59-2 Chemical ID: MESH:D003981

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:70982	6480464	CTD	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein] Enalapril inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein]	PMID:18806606
multiple interactions	ISO	RGD:70982	6480464	CTD	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]	PMID:16716347
multiple interactions	ISO	RGD:70982	6480464	CTD	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one promotes the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]	PMID:15951400
decreases phosphorylation	ISO	RGD:70982	6480464	CTD	Isoproterenol results in decreased phosphorylation of GSK3B protein	PMID:18806606
increases phosphorylation	ISO	RGD:70982	6480464	CTD	Isoproterenol results in increased phosphorylation of GSK3B protein	PMID:15951400 PMID:16716347
increases phosphorylation	ISO	RGD:70982	6480464	CTD	Isoproterenol results in increased phosphorylation of GSK3B protein	PMID:16716347 PMID:15951400