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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626 Species: Rattus norvegicus RGD Object: Gene Symbol: Fos Name: FBJ osteosarcoma oncogene

Acc ID: CHEBI:4495 Term: diazoxide Definition: A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies. CasRN: 7683-59-2 Chemical ID: MESH:D003981

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10596	6480464	CTD	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA]	PMID:18089841
increases expression	ISO	RGD:10596	6480464	CTD	Isoproterenol results in increased expression of FOS mRNA	PMID:18089841
multiple interactions	ISO	RGD:10596	6480464	CTD	[Phenylephrine co-treated with Isoproterenol] results in increased expression of FOS mRNA	PMID:10710348
multiple interactions	EXP		6480464	CTD	CREM protein inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA]	PMID:12791704
multiple interactions	EXP		6480464	CTD	Isoproterenol promotes the reaction [JUN protein binds to FOS protein]	PMID:14764439
increases expression	EXP		6480464	CTD	Isoproterenol results in increased expression of FOS	PMID:7905536
increases expression	EXP		6480464	CTD	Isoproterenol results in increased expression of FOS mRNA	PMID:7544033
multiple interactions	EXP		6480464	CTD	Propranolol inhibits the reaction [Isoproterenol results in increased expression of FOS]	PMID:7905536
increases expression	ISO	RGD:10596	6480464	CTD	Isoproterenol results in increased expression of FOS mRNA	PMID:18089841 PMID:21177286
multiple interactions	ISO	RGD:10596	6480464	CTD	[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA] U 0126 inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA]	PMID:21177286
increases expression	ISO	RGD:10596	6480464	CTD	Isoproterenol results in increased expression of FOS protein	PMID:21177286